If you have postfix configured in your /etc/mail/mailer.conf (answered yes to the previous question) and would like to enable postfix to start at boot time, please set these variables in your /etc/rc.conf file: sendmail_enable="YES" sendmail_flags="-bd" sendmail_pidfile="/var/spool/postfix/pid/master.pid" sendmail_procname="/usr/local/libexec/postfix/master" sendmail_outbound_enable="NO" sendmail_submit_enable="NO" sendmail_msp_queue_enable="NO" This will disable Sendmail completely, and allow you to use /etc/rc.d/sendmail to start and stop postfix (FreeBSD 5.x and up). For FreeBSD 4.x, it will just cause the system boot scripts to start sendmail for you. Alternatively to the above settings, you can enable postfix to start with the other local services, for example, after your database server starts if you need it to be running for postfix. To do this, set in your rc.conf file: sendmail_enable="NO" sendmail_submit_enable="NO" sendmail_outbound_enable="NO" sendmail_msp_queue_enable="NO" Then make the following symbolic link: cd /usr/local/etc/rc.d ln -s /usr/local/sbin/postfix postfix.sh With either startup configuration, you will want to disable some Sendmail-specific daily maintenance routines in your /etc/periodic.conf file: daily_clean_hoststat_enable="NO" daily_status_mail_rejects_enable="NO" daily_status_include_submit_mailq="NO" daily_submit_queuerun="NO" If you are using SASL, you need to make sure that postfix has access to read the sasldb file. This is accomplished by adding postfix to group mail and making the /usr/local/etc/sasldb* file(s) readable by group mail (this should be the default for new installs). If you are upgrading from postfix version prior to 2.0, please see the README files for recommended changes to your configuration.